Endocrine Abstracts

Background: Thyroid dysfunction is associated with increased cardiovascular morbidity and mortality. Early detection may influence the clinical management of the patients. There is insufficient data about the prevalence and clinical significance of thyroid dysfunction in cardiovascular hospitalized patients.Aims: To study the prevalence of thyroid dysfunction in cardiovascular hospitalized patients, to characterize patients with high prevalence of thyroi...

Introduction: Many studies have examined maternal and fetal complication rates in treated and untreated overt and subclinical hypothyroidism. Maternal hypothyroidism may adversely affect the development of the fetal pituitary–thyroid axis. It has also been reported to be closely related to adverse pregnancy outcome.Aim: To study the prevalence and outcome of hypothyroidism in pregnancy during the last decade in a high volume obstetric center in Jeru...

Background: Hospital physicians are indoor workers, with higher prevalence of vitamin D deficiency as compared to community-based physicians. The correlation between vitamin D deficiency and osteoporosis later in life has not been fully studied, and bone mineral density (BMD) in elderly hospital physicians has not been systematically examined.Methods: A cross-sectional study measuring BMD in hospital male physicians aged 65 and older was carried out. BMD...

Introduction: The prevalence of diabetes continues to increase worldwide. Diabetes distress (DD) defined as patient concerns about disease management, support, emotional burden, and access to care. It is distinct from depression.Aim: To document the prevalence of Diabetes related distress.Objectives: 1. Determine the level of distress among the study population.2. Determine the proportion of those with high d...

Background: Recent studies suggest that metformin (MF) may reduce TSH concentration. This fact could imply a dosage reduction of levothyroxine among those hypothyroid patients taking metformin.Aim: To determine, in a retrospective analysis, the impact of metformin in thyroidectomized patients (a condition not influenced by endogenous thyroid hormone production) on levothyroxine replacement.Patients and methods: One hundred ninety t...

Background: One of the major complications developed by patients with end stage renal disease (ESRD) is secondary hyperparathyroidism (SHPT), due to hypocalcaemia, hyperphosphatemia and 1,25(OH)2D deficiency with parathyroid hyperplasia and high PTH levels as earliest changes, which may require parathyroidectomy (PTX).Study design and objectives: This study aimed to evaluate the indications, the particularities and outcomes post-PTX of patient...

One of the most important activating genetic aberrations in differentiated thyroid cancer (DTC) development pathways involves the RET/PTC–RAS–RAF–MAPK axis. Mutations in the RET gene are essential in medullary thyroid carcinoma (MTC). Sorafenib is the first compound to reach clinical practice that is capable of inhibiting all the RAF kinases. Moreover, it targets a panel of tyrosine kinase receptors, such as VEGF receptors which gives to sorafenib not only proap...

Endogenous Cushing’s syndrome is a rare disease, with an incidence of 0.7–2.4 per million people per year. Adrenal origin is described in approximately 20 percent of all cases. Adrenal lymphoma presenting as adrenal incidentaloma with autonomous cortisol production has recently been described, though this is a rare condition. We report a rare case of adrenal Cushing’s syndrome in a patient diagnosed with a low-grade non-Hodgkin’s lymphoma. Female patient, a...

There are still many questions remaining about the etiopathogenesis of thyroid cancer, themost common type of endocrine neoplasia. Numerous occupational and environmental exposureshave been shown to represent important risk factors that increase its incidence. Updated informationabout thyroid cancer diagnostics related to occupational and environmental risk factors is reviewedhere, considering an integrated risk assessment approach; new data concerning thyroid canceretiology a...

Some patients with type 2 diabetes mellitus (T2DM) suffer from severe acquired insulin resistance (IR). There is still a shortage of research analyzing the T2DM patients with severe IR and identifying their risk factors.Aim: To evaluate how selected sociodemographic and metabolic factors are linked to severe IR among patients with T2DM.Methods: It was a case control study. If T2DM patients received high insulin doses (>1 IU/kg/...